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Christopher J Froelich Selected Research

Perforin

2/2017Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis.
3/2015Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.
8/2012Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice.
1/2011Human perforin employs different avenues to damage membranes.
6/2010Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.
3/2009Granule-associated serine proteases: granzymes might not just be killer proteases.
6/2008NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.
3/2008Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes.
6/2005Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.
11/2004Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.
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Christopher J Froelich Research Topics

Disease

10Neoplasms (Cancer)
01/2016 - 10/2002
4Infections
07/2014 - 09/2004
2Sepsis (Septicemia)
02/2017 - 07/2014
2Inflammation (Inflammations)
01/2016 - 04/2009
2Arthrogryposis renal dysfunction cholestasis syndrome
06/2013 - 01/2011
1Rheumatoid Arthritis
02/2017
1Arthritis (Polyarthritis)
02/2017
1Experimental Arthritis
02/2017
1Bacterial Infections (Bacterial Infection)
07/2014
1Hepatitis
08/2012
1Acquired Immunodeficiency Syndrome (AIDS)
01/2011
1Carcinoma (Carcinomatosis)
02/2005
1Leukemia
11/2004
1Lymphoma (Lymphomas)
11/2004
1Adenocarcinoma
03/2004
1Breast Neoplasms (Breast Cancer)
03/2004

Drug/Important Bio-Agent (IBA)

13Granzymes (Granzyme)IBA
02/2017 - 10/2002
12PerforinIBA
02/2017 - 10/2002
4Proteins (Proteins, Gene)FDA Link
06/2013 - 06/2008
3Serine Proteases (Serine Protease)IBA
01/2016 - 06/2008
2Peptide Hydrolases (Proteases)FDA Link
02/2017 - 07/2014
2CytokinesIBA
02/2017 - 07/2014
2Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
02/2005 - 10/2002
1Collagen Type II (Type II Collagen)IBA
02/2017
1VaccinesIBA
01/2013
1Antiviral Agents (Antivirals)IBA
08/2012
1LipidsIBA
01/2011
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
09/2008
1TubulinIBA
06/2008
1ezrinIBA
06/2008
1ProteomeIBA
06/2008
1gamma-AIBA
03/2008
1IntegrinsIBA
06/2005
1SerpinsIBA
02/2005
1Messenger RNA (mRNA)IBA
11/2004
1Interferon-gamma (Interferon, gamma)IBA
11/2004
1WT1 ProteinsIBA
11/2004
1LigandsIBA
03/2004
1CaspasesIBA
03/2004
1Glucose (Dextrose)FDA LinkGeneric
03/2004
1Caspase 3 (Caspase-3)IBA
03/2004
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2004

Therapy/Procedure

1Immunotherapy
01/2013